人微粒体孵育法测定射干合剂中麻黄碱体外代谢率
Guiding Journal of Traditional Chinese Medicine and Pharmacology（2017）
Abstract
目的:在人微粒体中验证射干合剂中麻黄碱与利多卡因合用体外孵育时代谢酶.方法:采用人微粒体体外孵育法,高效液相色谱法测定麻黄碱、利多卡因及其代谢产物浓度,对合用前后、孵育前后原形药物及其代谢物进行比较.结果:根据Dixon作图法,表明麻黄碱和利多卡因合用符合竞争抑制.结论:射干合剂中含有麻黄碱成分,在临床使用中应注意药物的相互作用产生.
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Key words
ephedrine,SGHT,lidocaine,metabolism
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