参卿止痒洗液急性毒性与皮肤刺激性实验
Guiding Journal of Traditional Chinese Medicine and Pharmacology（2016）
Abstract
目的:对参卿止痒洗液进行皮肤急性毒性和皮肤刺激性实验,以了解其安全性.方法:参卿止痒洗液经皮给药用于大鼠背部完整皮肤、破损皮肤,观察其产生急性毒性情况;将临床用浓度的参卿止瘁洗液局部涂抹兔破损皮肤及完整皮肤,1次/d,连续7次,逐日观察、并记录各时间点动物局部皮肤的症状表现以评价参卿止痒洗液对皮肤的刺激性.结果:参卿止瘁洗液未产生急性毒性;参卿止瘁洗液对兔完整皮肤和破损皮肤均无明显刺激性.结论:参卿止瘁洗液以临床浓度、5倍临床浓度、10倍临床浓度外用给药安全,无急性皮肤毒性反应、皮肤与全身刺激反应.
MoreKey words
Shenqing anti-itch lotion,skin acute toxicity,dermal irritation,rat,rabbit
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