补肾养血方药对气态甲醛慢性染毒小鼠子宫内膜容受性的影响
Guiding Journal of Traditional Chinese Medicine and Pharmacology(2016)
Abstract
目的:探讨补肾养血方药对气态甲醛慢性染毒小鼠子宫内膜容受性的影响.方法:将30只性成熟SPF级雌性昆明种小鼠随机分为空白对照组、染毒组和中药治疗组,每组10只,空白对照组给予吸入经过滤的新鲜空气,染毒组和中药治疗组给予1.0mg/m3浓度气态甲醛动态吸入式染毒,6h/d,同时中药治疗组每日予补肾养血中药灌胃,空白对照组和染毒组予等量生理盐水灌胃,连续14d;将小鼠雌雄(2∶1)合笼处理,于孕5d处死小鼠,取出子宫,计算子宫脏器系数,观察胚胎着床情况;用RT-PCR和Real-time PCR法检测各组小鼠子宫Hoxa 10、Hoxa11 mRNA的表达.结果:染毒组小鼠子宫脏器系数、子宫Hoxa 10、Hoxa11 mRNA表达均低于空白对照组,差异均有统计学意义(P<0.05或P<0.01),胚胎着床数低于空白对照组,但差异无统计学意义(P>0.05).中药治疗组小鼠子宫Hoxa10、Hoxa11 mRNA表达高于染毒组,差异均有统计学意义(P<0.05或P<0.01).结论:补肾养血方药能使气态甲醛慢性染毒小鼠子宫Hoxa10、Hoxa11 mRNA表达升高,从而改善子宫内膜容受性.
MoreKey words
Traditional Chinese herbs with tonifying kidney and nourishing blood function,endometrial receptivity,Hoxa10,Hoxa11,mice
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