归肾丸对DOR小鼠卵巢超微结构的影响
Research of Integrated Traditional Chinese and Western Medicine(2014)
Abstract
目的:探讨归肾丸对卵巢储备功能低下(diminished ovarian reserve ,DOR)小鼠的颗粒细胞超微结构的影响。方法将20只C57 BL/6J雌性小鼠随机分为正常组、模型组、归肾丸组和脱氢表雄酮(DHEA)组。连续序贯腹腔注射孕马血清(PMSG)、人绒毛膜促性腺激素(HCG)、前列腺素 F2α(PGF2α)产生连续超数排卵,再结合臭氧吸入构建DOR模型。其后各治疗组给予相应药物灌胃,而正常组与模型组给予生理盐水灌胃。21 d后,采用透射电镜观察各组小鼠卵巢颗粒细胞超微结构的变化。结果模型组中线粒体肿胀明显,还出现了空泡化改变,且较少看到脂滴,各治疗组卵巢超微结构较模型组有明显差异,颗粒细胞线粒体形态规则,管型明显,胞质内脂滴丰富。结论归肾丸对 DOR模型小鼠卵巢超微结构有较明显的改善作用。
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Key words
diminished ovarian reserve,Guishenwan,ultrastructure,superovulation,DHEA
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