依那普利和替米沙坦对纤溶酶原激活物抑制剂-1和血浆可溶性细胞间黏附分子-1表达的影响
Clinical Journal of Traditional Chinese Medicine(2014)
Abstract
目的:研究依那普利和替米沙坦对原发性高血压大鼠(SHR)的血压和相关分子标记物表达的影响.方法:40只SHR大鼠,随机分为替米沙坦组(SHR-T)、依那普利组(SHR-E)、两药联合组(SHR-TE)和空白对照组(SHR-C).选取10只魏-凯氏大鼠(WKY),为正常对照组(WKY).治疗前后,测定血压、sICAM-1、PAI-1.结果:治疗组血压在治疗前后有显著差异(P<0.01).治疗组和WKY组的sICAM-1、PAI-1与SHR-C组有显著差异(P<0.01).治疗组的sICAM-1与WKY组有显著差异(P<0.01),其中单药组与联合组有显著差异(P<0.01).结论:替米沙坦和依那普利可显著降低血压、PAI-1和sICAM-1的表达.两者联合治疗对PAI-1的表达无明显优势.
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