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肌腱再生相关转录因子研究进展

Yun-long ZHAO,Yan-long QU,Qiang WANG,Qing MIAO,Peng-wei LI

Progress in Modern Biomedicine（2015）

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Abstract
肌腱作为骨骼和肌肉的连接往往容易受到损伤,目前对肌腱基本生物学有限的了解妨碍了肌腱修复技术的发展.最近,一系列肌腱生长相关因子被发现,其中Scleraxis(Scx)和Mohawk(Mkx)已被确定为肌腱生长和分化中的关键转录因子,Sox9和EGR1/2也被报道参与肌腱的生长.然而,目前研究尚未明确这些转录因子的生物学功能及其分子机制.本文就上述转录因子的分布与功能,及转录因子相关分子进行综述,为肌腱的修复提供生物学基础并探讨肌腱损伤治疗的未来发展方向.
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Key words
Tendon transcription factors,Scleraxis,Mohawk,Sox9,Egr1/2,Tendon regeneration
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