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Nrf2通过调控EZH2的表达促进DMSO诱导的MEL细胞红系分化

Wen DONG,Hao-wen LI,Li LIU,Ya-jie WANG

Labeled Immunoassays and Clinical Medicine（2017）

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Abstract
目的 探讨Nrf2/EZH2通路参与DMSO诱导MEL细胞红系分化的作用及相关分子机制.方法 以MEL细胞为靶细胞,DMSO为刺激源,联苯胺染色法检测细胞红系分化情况;免疫印迹检测EZH2和Nrf2蛋白表达水平.结果 DMSO可显著诱导MEL细胞红系分化,同时EZH2和Nrf2表达水平也明显升高.通过使用Nrf2诱导剂TBHQ及Nrf2 shRNA,证明Nrf2调控MEL细胞中EZH2的表达.敲低Nrf2和EZH2的表达能够抑制DMSO诱导的MEL细胞红系分化.结论 Nrf2可通过调控EZH2的蛋白水平从而发挥促进MEL细胞红系分化的作用.
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Key words
Nrf2,EZH2,MEL cells,Erythroid differentiation
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