P53蛋白在葡萄胎中表达的Meta分析
International Journal of Pathology and Clinical Medicine(2018)
Abstract
目的:系统评价P53蛋白在葡萄胎(hydatidiformmole,HM)中的表达与鉴别诊断作用.方法:检索Pubmed,Medline,Embase,CNKI,WanfangData,VIP及CBM数据库,并追溯相关参考文献.选择RevMan 5.3版本进行Meta分析,采用Begg's,Egger's分析纳入文献的发表偏倚.结果:共纳入18个研究,包括完全性葡萄胎(complete hydatidiform mole,CHM)436例,部分性葡萄胎(partial hydatidiform mole, PHM)369例和水肿性流产(hydropic abortus,HA)220例.Meta分析结果示CHM组P53表达明显高于PHM组(OR=2.84,95%CI 2.00~4.04,P<O.001);亚组分析结果示在欧洲人中,CHM组与PHM组中P53表达无统计学意义(OR=0.55,95%CI 0.16~1.85,P=0.33);在亚洲人中,CHM组P53表达明显高于PHM组(OR=3.36, 95%CI 2.31~4.88,P<0.001); CHM与PHM组的P53阳性率均明显高于HA组(OR=32.15,95%CI 18.97~54.49,P<0.001; OR=13.11,95%CI 8.21~20.93, P<0.001).结论:P53蛋白的高表达可能在HM的发生发展中起重要作用.
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Key words
hydatidiform mole,P53 protein,Meta-analysis,case-control study
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