Chrome Extension
WeChat Mini Program
Use on ChatGLM
VIPCreated with Sketch.

GDNF与消化系统肿瘤关系研究进展

Xiao-juan WANG,Xiao-li LI,Zheng-xu JIN,De-kui ZHANG

Basic & Clinical Medicine（2020）

Cited 0|Views4
No score
Abstract
肠神经胶质细胞源性神经生长因子(GDNF)及其受体(RET)的异常表达与消化系统肿瘤的发生、发展及预后相关.胰腺癌中,GDNF及其受体RET与周围神经侵袭相关并呈剂量依赖性,RET(-)癌细胞则失去了侵袭并且破坏神经的能力;结肠癌中,RET突变促进结肠癌细胞增殖、迁移及存活,且与结肠癌患者预后较差相关;肝癌中,GDNF可独立于血管源性生长因子促进肝癌组织血管生成,为肿瘤细胞的增殖侵袭提供充足的营养;胃癌中发现GFRα3启动子区域甲基化,且其程度和术后患者存活率之间呈反比关系.
More
Translated text
Key words
glial cell line-derived neurotrophic factor(gdnf)|liver cancer|colorectal cancer|pancreatic cancer|gastric cancer
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined