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PKM2与头颈部鳞状细胞癌淋巴结转移及临床分期相关性的Meta分析

周剑,刘欢, 张惠紫,杨志惠

Chinese Journal of Clinical and Experimental Pathology（2019）

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Abstract
目的 探讨PKM2与头颈部鳞状细胞癌(head and neck squamous cell carcinoma,HNSCC)淋巴结转移及临床分期的相关性.方法 检索PubMed和EMBASE数据库,最终纳入5篇文献共611例HNSCC组织标本进行Meta分析,分析指标包括淋巴结转移和临床分期.结果 HNSCC组织中PKM2表达与淋巴结转移(OR =0.43,95％ CI =0.29 ～0.64,P ＜0.000 1)和临床分期(OR=0.33,95％CI=0.22 ～0.48,P＜0.000 01)呈显著性相关.结论 HNSCC组织中PKM2表达与淋巴结转移及临床分期具有相关性,提示PKM2可作为HNSCC淋巴结转移及临床分期的预测指标.
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