117例甲状腺结节FNAC检查与BRAF基因联合检测的结果分析
Chinese Journal of Clinical and Experimental Pathology(2018)
Abstract
目的 探讨超声引导下甲状腺细针穿刺细胞学检查(fine needle aspiration cytology,FNAC)与丝/苏氨酸特异性激酶(serine-threonine protein kinase,BRAF)基因V600E联合检测对于甲状腺结节的临床应用价值.方法 收集117例甲状腺结节患者,术前分别行FNAC检查和BRAF V600E突变检测,并将其结果与术后病理诊断结果进行对比分析.结果 术前FNAC与BRAF V600E突变联合检测的符合率为92.3% (108/117),灵敏度为88.5% (69/78),均高于单独的BRAF V600E突变检测,差异有统计学意义(P<0.05).两者联合检测的灵敏度也高于单独的FNAC检查,差异有统计学意义(P<0.05).结论 甲状腺FNAC细胞学评估与BRAF基因联合检测可提高甲状腺结节的术前诊断率,并对临床有重要的指导意义.
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