碘海醇脂质体的制备及其质量评价
JOURNAL OF BIOMEDICAL ENGINEERING(2007)
Abstract
采用逆相蒸发法制备碘海醇脂质体.对脂质体的形态、包封率、粒径分布、体外释放及体内造影情况等性质进行研究.透射电镜下观察脂质体为粒径均匀的球状或近球状小囊泡.HPLC法测定碘海醇脂质体包封率为82.35%±1.82%.碘海醇脂质体平均粒径207.7 nm,分散指数0.355,Zeta电位-1.83 mV.体外释放度试验表明碘海醇脂质体中药物的释放明显比碘海醇单纯药物缓慢,24 h才达到98.57%.体内试验结果表明脂质体包裹的造影剂比普通造影剂CT峰值推后,信号增强,作用时间延长.碘海醇脂质体包封率较高、重现性良好.将碘海醇包裹于脂质体后减少给药剂量、延长作用时间,并可能减小对血管和中枢神经的毒性.
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Key words
liposomes
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