抗结核药物肝损害对老年肺结核患者血清TNF-α、CG及CA-199水平影响
Journal of Clinical Medicine in Practice（2016）
Abstract
目的 探讨抗结核药物肝损害对老年肺结核患者外周血肿瘤坏死因子-α (TNF-α)、甘胆酸(CG)及糖类抗原199(CA-199)水平的影响及与肝损害相关指标的相关性.方法 34例因服用抗结核药物出现药物肝损害肺结核患者设为观察组,32例老年健康人群作为对照组.结果 观察组患者血清中TBIL、ALT及ALP水平显著高于对照组(P＜0.05);观察组患者血清中TNF-α、CG及CA-199水平显著高于对照组(P＜0.05).观察组患者血清中TNF-α、CG及CA-199水平与ALT均呈正相关(P＜0.05).结论 抗结核药物肝损害可促进老年肺结核患者血清中TNF-α、CG及CA-199的表达.
MoreKey words
elderly,pulmonary tuberculosis,hepatic lesion,anti tuberculosis drugs
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