人表皮生长因子受体-2和细胞增殖抗原Ki67与乳腺癌前哨淋巴结转移的关系
Journal of Chinese Practical Diagnosis and Therapy(2016)
Abstract
目的 分析乳腺癌患者中人表皮生长因子受体-2(human epidermal growth factor receptor-2,HER-2)与细胞增殖抗原Ki67的表达状态,探讨其与乳腺癌前哨淋巴结转移的关系.方法 手术治疗121例乳腺癌患者,术中均行前哨淋巴结活检组织病理;采用免疫组织化学法检测乳腺癌组织中HER-2与Ki67的表达情况;采用HE染色法及免疫组织化学法检测前哨淋巴结转移情况;分析HER-2、Ki67与前哨淋巴结转移的相关性.结果 HER-2与Ki67在乳腺癌组织中阳性率分别为55.37%、71.90%;前哨淋巴结转移率为32.23%(39/121);前哨淋巴结转移与HER-2(r=1.000,P=0.000)及Ki67(r=0.994,P=0.006)阳性表达率呈正相关.结论 HER-2及Ki67表达情况可作为辅助评估前哨淋巴结是否转移的重要因素.
MoreKey words
Breast cancer,sentinel lymph node,human epidermal growth factor receptor-2,proliferating antigen Ki67
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