EVI1阳性急性髓细胞白血病临床及预后分析
PRACTICAL JOURNAL OF CLINICAL MEDICINE(2014)
Abstract
分析EVI1(ectotropic vira lintegration site 1)基因在急性髓细胞白血病(AML)中的表达及意义.应用相对荧光定量PCR检测145例AML患者EVI1基因的表达,并观察其诱导缓解及生存情况.28例AML患者表达EVI1基因,阳性表达率19.3%;AML各亚型间比较,M4、M5的EVI1基因阳性率高于M1、M2(χ2=16.47,P<0.05).EVI1阳性与阴性患者年龄、外周血白细胞、血红蛋白、血小板、骨髓原始幼稚细胞比例及完全缓解率等比较,差异均无统计学意义(P>0.05).但EVI1阳性患者的1年内病死率明显高于EVI1阴性患者(χ2=9.68,P<0.05).EVI1基因在AML的发病中起一定作用,可作为判断AML 预后不良的一个指标.
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