标准化ADC评估宫颈癌的组织学类型及分化程度
Chinese Computed Medical Imaging(2017)
Abstract
目的:探讨标准化ADC (nADC)在鉴别宫颈癌组织学类型及病理分级的价值.方法:65例经病理确诊的富颈癌患者治疗前行常规磁共振成像(MRI)和扩散加权成像(DWI),获取肿瘤ADC值.选取患者尿液和臀大肌作为参照物,计算nADC(肿瘤ADC值/参照物ADC值).结果:宫颈鳞癌组的ADC值、nADC(尿液)、nADC(臀大肌)明显低于腺癌组,差异具有统计学意义(均P<0.001).ADC值、nADC(尿液)、nADC(臀大肌)和细胞密度在宫颈鳞癌不同分化组中有统计学差异(P分别为<0.001,<0.001,<0.001和0.004).在鉴别宫颈鳞癌与腺癌、鳞癌的分化程度时,nADC(臀大肌)的诊断效能最高.nADC(臀大肌)与细胞密度的相关性最好,相关系数r为-0.785.结论:nADC能够鉴别宫颈癌的组织学类型和分化程度,并且优于肿瘤ADC值.
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Key words
Uterine cervical neoplasms,Diffusion-weighted MR imaging,Apparent diffusion coefficient,Cellular density,Pathological grade
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