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T K1检测对常见恶性肿瘤诊断的临床应用

International Journal of Laboratory Medicine(2014)

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Abstract
目的:探讨胸苷激酶1(TK1)对常见恶性肿瘤诊断的临床应用。方法采用酶免疫点印迹化学发光法检测444例肿瘤患者和161例健康体检者(对照组)血清中T K1水平。结果与对照组比较,肺癌、消化道肿瘤、乳腺癌患者血清 T K1水平均显明显升高(P<0.05)。肺癌、食管癌、结肠癌、直肠癌、乳腺癌、宫颈癌、卵巢癌患者TK1检测阳性率,分别为52.0%、59.6%、62.9%、60.0%、62.1%、32.3%、21.4%、11.0%。与对照组(T K1检测阳性率为0.0%)比较,肺癌、消化道肿瘤、乳腺癌 T K1检测阳性率明显升高(P<0.01)。结论血清TK1检测在常见恶性肿瘤的辅助诊断上是一个有价值的指标。
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Key words
serum thymidine kinase 1,tumor,tumor marker
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