血清可溶性凝集素样氧化低密度脂蛋白受体1早期诊断急性ST段抬高型心肌梗死的价值
Clinical Medicine of China（2014）
Abstract
目的 探讨血清可溶性凝集素样氧化低密度脂蛋白受体1(sLOX-1)早期诊断急性ST段 抬高型心肌梗死(STEAMI)的价值.方法 入选STEAMI组患者65例,对照组30例为稳定性冠心病或非冠心病的心脏病患者,所有患者入院时立即抽血测定血清sLOX-1.结果 STEAMI组血清sLOX-1明显高于对照组[以中位数(P25,P75)表示:210.0(130.0,356.0) ng/L与65.5(55.2,85.2) ng/L,Z=6.17、P＜0.001],Logistic回归显示血清sLOX-1与STEAMI独立相关(回归系数值为0.036,P＜0.001).血清sOX-1诊断STEAMI的ROC曲线下面积为0.895,95％CI:0.831 ～0.959,P＜0.001.以87.5 ng/L为截断值,敏感性84.6％,特异性80％.结论 sLOX-1在STEAMI时明显升高,具有早期诊断STEAMI的价值.
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Key words
Soluble lectin-like oxidized low-density lipoprotein receptor-1,Acute ST elevation myocardial infarction,Logstic analysis
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