丙型肝炎抗体S/CO值与RNA定量检测结果相关关系的初步探讨
Journal of Modern Laboratory Medicine(2013)
Abstract
目的 探讨免疫发光法检测丙肝抗体S/CO(signal to cutoff)值与HCV RNA检测阳性率之间的关系.方法 对1111例丙肝患者行HCV抗体和HCV RNA的实验室检测,以抗体水平进行分段统计,并以HCV RNA检测结果为参考采用ROC曲线评价S/CO值对丙肝患者的诊断效能.结果 HCV RNA阳性率随S/CO值的增大而升高,S/CO值在0~1时,HCV RNA阳性率为1.09%;在1~5时,阳性率为5.06%;在5~8时,阳性率为24.5%;8~10时,为50%;>10,阳性率为100%.同时发现,S/CO值较低时HCV RNA阳性病例多为HIV/HCV共感染患者.根据ROC曲线可知,S/CO最佳诊断界值为6.94,此时诊断灵敏度和特异度均为93%.结论 丙肝抗体S/CO值与HCV RNA检测结果较一致,临床实践中可参考S/CO值,并充分考虑患者实际情况,以合理选择检验项目,提高诊断效能.
MoreKey words
the value of the S/CO,quantitative HCV RNA detection,detection efficacy
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