2型糖尿病肾病与血清胆红素的关系
Clinical Focus(2017)
Abstract
目的 通过研究2型糖尿病肾病患者血清胆红素浓度水平以探讨其在微血管病变的临床意义.方法 选取2型糖尿病患者525例,以尿白蛋白肌酐比值(ACR)为分组依据,分为正常白蛋白尿组(尿ACR正常:即男<2.5 mg/mmol,女<3.5 mg/mmol)299例;早期糖尿病肾病组(尿ACR男:2.5~30.0 mg/mmol,女3.5~30.0 mg/mmol)116例;临床糖尿病肾病组(尿ACR>30 mg/mmol且排外肾衰竭患者)110例.比较3组患者血清胆红素水平的差异.应用非条件Logistic逐步回归法对其危险因素进行多因素分析.结果 临床糖尿病肾病组血清总胆红素,直接胆红素,间接胆红素,较早期糖尿病肾病组、正常白蛋白尿组均低(P<0.05).非条件Logistic逐步回归法显示血清总胆红素是糖尿病肾病的保护因素.结论 血清总胆红素水平与2型糖尿病肾病的进展呈负相关.
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Key words
diabetic nephropathies,oxidative stress,bilirubin,urinary albumin-to-creatinine ratio
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