PRKAA2基因多态性与阿托伐他汀对2型糖尿病患者降脂稳定斑块疗效的关系

Zhejiang Clinical Medical Journal(2017)

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Abstract
目的 探讨PRKAA2基因多态性与阿托伐他汀钙在2型糖尿病伴动脉粥样硬化患者降脂稳定斑块作用的相关性.方法 2型糖尿病伴动脉粥样硬化患者203例,常规口服阿托伐他汀3个月后复查颈部B超,按照颈动脉斑块预后结果分显效组(116例)及失效组(87例),应用基因测序技术检测PRKAA2基因多态性.结果 显效组PRKAA2基因多态性(rs2796516位点)G等位基因频率显著高于失效组(64.7%vs 54.6%),显效组GG基因型显著高于失效组(39.7%vs 33.3%),差异有统计学意义(P<0.05).余基因型比较差异无统计学意义.结论 PRKAA2基因(rs2796516)位点与阿托伐他汀钙降脂稳定斑块的效果存在一定的相关性,单倍型模块(rs1124900-rs2796516-rs2746342-rs2051040-rs2796498-rs17848595-rs1418442)的GATCAAT单倍型对阿托伐他汀钙降脂稳定斑块的失效也存在一定作用.
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Key words
AMP-activated protein kinase(AMPK),Gene polymorphism,Atherosclerosis
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