BML-111对野百合碱致大鼠肺动脉高压的作用及其机制的研究
Zhejiang Clinical Medical Journal(2015)
Abstract
目的:观察脂氧素受体激动剂BML-111对野百合碱(MCT)诱导肺动脉高压大鼠的作用及其机制。方法选择SD大鼠24只,随机分为三组:C组、pH组、B组,pH组和B组大鼠行皮下注射野百合碱50μg/g,C组注射等量生理盐水,B组腹腔注射BML-1111mg/(kg·d),连续4周。观察平均肺动脉压力(MPAP)、右心室收缩压(RVSP)、右心室(RV)/[左室(LV)+室间隔(S)]、肺组织白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平的变化。结果 pH组、B组与C组比较,MPAP、RVSP、RV/(LV+S)、肺组织IL-6及TNF-α水平高于C组(P<0.05);B组与pH组比较,MPAP、RVSP、RV/(LV+S)、肺组织IL-6及TNF-α低于pH组(P<0.05)。结论脂氧素受体激动剂BML-111可减轻野百合碱诱导肺动脉高压大鼠肺动脉压力,其机制可能与减轻肺组织IL-6及TNF-α水平,抑制肺组织炎症有关。
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Key words
Monocrotaline Pulmonary,Arterial Hypertension,Rats
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