浅谈PD1/PDL1拮抗剂联合CAR-T细胞治疗淋巴瘤的现状及进展

Systems Medicine(2020)

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Abstract
淋巴瘤是一种常见的血液系统肿瘤,目前化疗效果仍不理想.近年来,CART治疗恶性淋巴瘤取得了不错的临床效果,但仍有部分患者无法获益,其相关机制可能与PD1/PDL1的表达有关,联合应用程序性死亡受体及其配体(programed death,PD)PD1/PDL1拮抗剂可进一步提高恶性淋巴瘤的治疗效果,仍需要更多的循证医学证据来进一步证实.
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