亚甲基四氢叶酸还原酶基因多态性同型半胱氨酸浓度和脑梗死的相关性研究
Journal of Practical Medical Techniques(2017)
Abstract
目的 探讨亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性、血浆同型半胱氨酸(Hcy)浓度和脑梗死的相关性,为脑梗死的防治提供依据.方法 应用聚合酶链反应(PCR)-RFLP方法检测215例脑梗死患者和200名健康对照者的MTHFR基因C677T多态性,并用循环酶法测定2组的血浆Hcy浓度,比较2组间MTHFR基因型和Hcy浓度的差异,以及基因型与Hcy浓度的相关性.结果 215例脑梗死患者中MTHFR基因TT型、CT型和T等位基因频率(7.4%,30.7%,22.8%)高于对照组(1.5%,15.5%,9.2%)(x2=8.374,P=0.004,OR=5.28,x2=13.362,P=0.000,OR=2.41;x2=27.898,P<0.01,OR=2.90).脑梗死组和对照组平均Hcy浓度分别为(13.18±6.24)μmol/L和(10.26±3.42)μmol/L,脑梗死组的Hcy浓度显著高于对照组(P=0.000),TT基因的血浆Hcy浓度均显著高于CT型(P=0.019)和CC型(P=0.004),而CT型与CC型的Hcy浓度之间差异均无统计学意义(P=0.107).结论 MTHFR基因C677T突变可影响Hcy水平,可能与脑梗死的发生密切相关.
MoreAI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined