米非司酮配伍米索前列醇二种不同给药途径终止孕10-16周妊娠的临床观察
JOURNAL OF CHINESE CLINICAL MEDICINE(2004)
Abstract
目的观察米非司酮配伍米索前列醇口服法与阴道给药法对终止早中期妊娠疗效.方法米非司酮25mg,每12小时口服1次×5次,首剂加倍,末次给药后3h,口服药组:口服米索前列醇400 μ g,根据宫缩强弱每3h/次,最多不超过5次.阴道给药组:米索前列醇600 μ g,水化后置入阴道后穹窿,根据宫缩强弱,12小时后可重复给药1次.结果口服药组:103例,有效率达95%,产程时间:14.10±2.98小时,出血量62.33±7.50ml,用药量1320±255 μ g.阴道给药组:102例,有效率达97%,产程时间7.30±1.52小时,出血量61.11±7.10ml,用药量660±259 μ g.结论米索前列醇阴道给药明显优于口服药,缩短产程时间(P<0.01),减少用药量(P<0.01),降低药费:阴道出血及成功率二组无显著差异(P>0.05).
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