暴发性1型糖尿病研究新进展
Chinese Journal of Diabetes（2018）
Abstract
暴发性1型糖尿病(FT1DM)是一种T1DM亚型,以迅速进展的胰岛β细胞破坏、高血糖症状和DKA,并缺乏糖尿病相关抗体为特征,被归入1B型糖尿病,属于糖尿病的急危重症.FT1DM发病与人类白细胞抗原基因型有关,免疫及肠道病毒等参与发病,但发病机制尚不明确.FT1DM与T2DM有关,既往T2DM病史者不能排除FT1DM.孕期胰岛自身免疫可能参与并促进FT1DM的发展,孕妇是该病高发人群,胎儿预后极差.
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Key words
Diabetes mellitus,type 1,fulminant,Human leukocyte antigen,Immunity,Enteroviruses
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