糖尿病视网膜病变患者血清可溶性CD40配体水平的变化及其临床意义
Chinese Journal of Diabetes(2015)
Abstract
目的:探讨不同分期DR患者血清可溶性CD40配体(SCD40L )水平的变化及其临床意义。方法将91例T2DM患者分为单纯T2DM组36例、非增殖型DR(NPDR)组30例和增殖型DR(PDR)组25例,另选体检健康者25名为健康对照(NC)组。采用ELISA检测各组血清SCD40L水平。结果T2DM组血清SCD40L水平较NC组高[(310.17±37.78) vs (200.34±14.21)pg/ml ,P<0.05],NPDR、PDR组较T2DM 组高[(384.89±37.78),(480.52±47.17) vs (310.17±37.03)pg/ml ,P<0.05],且PDR组较NPDR组高[(480.52±47.17) vs (384.89±37.78)pg/ml ,P<0.05]。Logistic回归分析结果显示,病程、SCD40L为DR的影响因素。结论 DR患者血清SCD40L水平升高,SCD40L在DR发生发展中起重要作用。
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Key words
Diabetic mellitus,type 2,Diabetic retinopathy (DR),Soluble CD40 ligand (SCD40L)
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