血浆非对称性二甲基精氨酸水平与2型糖尿病患者脑微出血的相关性研究
Chinese Journal of Geriatric Heart Brain and Vessel Diseases(2016)
Abstract
目的 探讨血浆非对称性二甲基精氨酸(ADMA)与2型糖尿病患者脑微出血(CMB)的相关性.方法 122例2型糖尿病患者采用3.0 T MRI确定是否存在CMB,并分为CMB组27例,非CMB组95例.应用ELISA法检测患者血浆ADMA水平.结果 CMB组较非CMB组年龄偏大[(62.25±8.01)岁vs (57.68±11.15)岁,P=0.020)],高血压比例高[(77.8% vs 44.2%,P=0.002)],血浆ADMA升高[(1.6(1.2,2.0) μmol/L vs 1.3(1.1,1.5) μmol/g,P=0.004)],估算肾小球滤过率[81(70,94)ml/(min·1.73 m2)vs99(82,112)ml/(min·1.73 m2),P=0.000]降低.血浆高ADMA水平是CMB存在及部位(深部/幕下型)独立危险因素(OR=3.564,95%CI:1.038~12.235,P=0.043;OR=8.657,95%CI:1.896~39.517,P=0.005).结论 2型糖尿病患者血浆ADMA水平与CMB的存在及CMB发生位置密切相关.
MoreKey words
diabetes mellitus,type 2,cerebral hemorrhage,hypertension,glomerular filtration rate
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