金雀异黄素对甲状旁腺素诱导的人近曲小管上皮细胞转分化及结缔组织生长因子表达的影响
CHINESE JOURNAL OF INTERNAL MEDICINE（2010）
Abstract
肾间质纤维化(RIF)是慢性肾脏疾病进展,最后导致肾功能衰竭的共同途径.研究表明肾小管上皮细胞转分化(EMT)启动了RIF的进程.结缔组织生长因子(CTGF)已被公认具有致纤维化效应.金雀异黄素(Gen)是酪氨酸激酶、DNA拓朴异构酶Ⅱ和核糖体S6激酶的抑制剂,目前尚无研究报道Gen抑制甲状旁腺素(PTH)引起的肾小管间质纤维化.
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