Serum Levels Of Inflammatory Cytokines And Oxidative Stress State In Patients With Amnestic Mild Cognitive Impairment

Objective To observe the serum level change of high sensitivity C-reactive protein (hs-CRP),superoxide dismutase (SOD),glutathione peroxidase (GSH Px) and malondialdehyde (MDA) in patients with amnestic mild cognitive impairment (aMCI).Methods Using case-control research,68 aMCI patients (aMCI group) and 56 normal elderly (control group) from community were collected.The serum levels of hs-CRP,SOD,GSH Px and MDA were analyzed and compared.Results The hs-CRP level was significantly higher in aMCI group than in control group [(3.57±3.75) mg/L vs.(2.33±2.03) mg/L,t=2.34,P=0.021].There were no significant difference between aMCI and control groups in the levels of SOD [(26.88±8.34) × 103 U/L vs.(28.27±6.79) × 103 U/L,t=-1.00,P=0.319],MDA [(9.12±4.51) μmol/L vs.(8.07±2.74) μmol/L,t=1.58,P=0.116) and GSH-Px (175.08±41.66) unit of enzyme activity vs.(177.84±47.80)unit of enzyme activity,t=0.34,P=0.732].Conclusions The serum level change of hs-CRP suggests that inflammation reaction may play an important role in the pathogenesis of aMCI.It may provide experimental reference for the anti-inflammatory therapy and prevention of aMCI.