黄芪甲苷对脑缺血再灌注后脑组织MPO活性及TNF α、IL 1β含量的影响
Chinese Journal of Integrative Medicine on Cardio/Cerebrovascular Disease(2015)
Abstract
目的:探讨黄芪甲苷对大鼠脑缺血再灌注后脑组织髓过氧化物酶(MPO)活性及肿瘤坏死因子α(TNF α)、白介素1β(IL 1β)含量的影响。方法将36例只 SD大鼠物随机分为假手术组、模型组、黄芪甲苷治疗组,每组12只。采用分光光度法及酶联免疫吸附法分别检测各组大鼠脑组织 MPO活性及 TNF α、IL 1β含量。结果与假手术组相比,模型组大鼠脑组织 MPO活性及TNF α、IL 1β含量明显增高(P<0.01);与模型组相比,黄芪甲苷治疗组大鼠脑组织MPO活性及TNF α、IL 1β含量明显减少(P<0.05)。结论黄芪甲苷可下调脑缺血再灌注后 MPO活性及 TNF α、IL 1β含量,从而减轻炎症反应,发挥脑保护作用。
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Key words
cerebral ischemia and reperfusion injury,astragaloside Ⅳ,myeloperoxidase,tumor necrosis factor alpha,interleukin 1 beta
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