NLRP3炎性体在尘肺病发病中的作用研究进展

Journal of Clinical Pulmonary Medicine(2020)

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Abstract
尘肺病是我国危害人数最多的职业病,2018年报道超过97.5 万例职业病病例,其中90%为尘肺病[1].尘肺是常见的职业性肺病之一,以尘粒所致的肺组织慢性炎症及弥漫性纤维化为特征[2] ,尽管病因已明确,但其发病机制还未被完全阐明.目前认为尘肺发病与NLRP3 炎性体参与的炎症反应及纤维化密切相关.
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