SCNN1B基因变异与高血压继发左室肥厚的关系
Journal of Clinical Cardiology(2016)
Abstract
目的:验证SCNN1B多态性与高血压相关的左室肥厚的关系.方法:采取病例对照研究,采用下一代测序(Next Generation Sequencing,NGS)技术对423例高血压非左室肥厚患者和275例高血压左室肥厚患者进行SCNN1B rs12447134位点多态性检测.所有患者进行心脏超声检测.结果:rs12447134 AA、AC、CC基因型在高血压左室肥厚组的频率分别为69.8%、25.1%、5.1%,在高血压非左室肥厚组中为73.9%、23.6%、2.4%,差异无统计学意义(P>0.05);按显性模式型分析及多因素logistic回归分析校正年龄、性别、BMI、SBP、DBP、血糖等传统危险因素后,在高血压左室肥厚组和高血压非左室肥厚组各心脏超声参数均无统计学差异,AC+CC基因型与高血压左室肥厚组风险的关联性无统计学意义(OR=1.230,95%CI:0.878~1.723,P=0.228).结论:SCNN1B基因多态性rs12447134与高血压相关左室肥厚可能无关.
MoreKey words
SCNN1B,gene polymorphism,essential hypertension,left ventricular hypertrophy
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined