稳定性冠心病患者半乳糖凝集素-3与血流储备分数相关性研究
Journal of Clinical Cardiology(2016)
Abstract
目的:探讨稳定性冠心病患者血清Galectin-3与血流储备分数(FFR)之间的关系.方法:连续入选2011-08-2014-12行FFR检测的单支病变稳定性冠心病274例,分为FFR>0.80组和FFR≤0.80组,ELISA检测患者血清Galectin-3表达水平.结果:FFR≤0.80组平均年龄58.9±8.3岁,男性比例、高血压患病率高于FFR>0.80组,入院前口服ACEI/ARB比例低于FFR>0.80组;FFR≤0.80组Galectin-3表达高于FFR>0.80组;Galectin-3独立于性别、吸烟、入院前口服阿司匹林和尿酸,是稳定性冠心病患者FFR≤0.80的独立预测因子(比值比:3.961,95%的置信区间为1.769~8.870,P=0.001).线性回归分析FFR值与Galectin-3独立相关.结论:稳定性冠心病患者,Galectin-3与FFR明显相关,是反映冠状动脉狭窄血管功能的重要指标.
MoreKey words
stable coronary artery disease,fractional flow reserve,galectin-3,biomarker
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