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急性药物性肝损伤患者肝脏硬度值测定及其影响因素分析

Ya' SUN,Feng XIONG,Yanjing WU,Yun ZHAI,Haibin YU,Peng LI,Xiaohong GUO,Shibin ZHANG

Chinese Journal of Gastroenterology and Hepatology（2017）

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Abstract
目的 分析急性药物性肝损伤(drug induced liver injury,DILI)患者治疗前后肝脏硬度测量值(liver stiffness measurement,LSM)的变化及其相关影响因素.方法 急性DILI患者30例,入院后完善肝功能等检测指标,并通过肝脏瞬时弹性超声(Fi-broScan,FS)测定其LSM,常规治疗2~6周后再次复查上述各项观察指标,通过多元相关分析探讨LSM的影响因素.结果 30例急性DILI患者治疗前后LSM差异有统计学意义(P=0.013);治疗前后检测TBIL、PTA的变化值与LSM变化量之间有相关性(P<0.05);多元回归分析显示TBIL水平与LSM呈正相关.结论 急性DILI患者的LSM随疾病好转呈下降趋势,TBIL会对LSM产生影响.
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Key words
Drug induced liver injury,Liver stiffness measurement values,Liver transient elastography,FibroScan
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