噻托溴铵联合布地奈德/福莫特罗对慢性阻塞性肺疾病患者血管内皮功能及T淋巴细胞亚群的影响
Journal of Cardiovascular and Pulmonary Diseases(2018)
Abstract
目的:探讨噻托溴铵联合布地奈德/福莫特罗对慢性阻塞性肺疾病患者血管内皮功能及T淋巴细胞亚群的影响.方法:将117例慢性阻塞性肺疾病患者按照随机数字表法,分为噻托溴铵治疗组(TB组)、布地奈德/福莫特罗治疗组(BF组)以及噻托溴铵联合布地奈德/福莫特罗治疗组(TCBF组),疗程四周,检测三组患者治疗前后临床疗效、内皮功能及T淋巴细胞亚群变化.结果:治疗后,TCBF组CAT评分、mMRC显著低于TB组、BF组,而FVC、FEV1、FEV1/FVC、6MWT显著高于TB组、BF组(P<0.05);TCBF组NO、VEGF高于TB组、BF组,而ET-1、ES显著低于TB组、BF组(P<0.05);TB组NO高于BF组,而ET-1低于BF组(P<0.05);TCBF组CD3+、CD4+及CD4 +/CD8+显著高于TB组、BF组(P<0.05);TB组CD3+、CD4+高于BF组(P<0.05).相关性分析显示,mMRC、CAT评分及FEV1/FVC与NO、VEGF、ES及CD3+、CD4 +/CD8+显著相关.结论:噻托溴铵联合布地奈德/福莫特罗治疗稳定期COPD患者临床疗效显著,可能与改善血管内皮功能、调节T淋巴细胞亚群有关.
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Key words
Chronic obstructive pulmonary disease,Tiotropium bromide,Budesonide/formoterol,Endothelial function,T lymphocyte factor
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