高致病性冠状病毒对抗宿主干扰素抗病毒系统作用的研究进展

Chinese Journal of Respiratory and Critical Care Medicine(2020)

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Abstract
冠状病毒属单股正链RNA病毒,其中严重急性呼吸综合征冠状病毒(severe acute respiratory syndrome coronavirus,SARS-CoV)和中东呼吸综合征冠状病毒(Middle East respiratory syndromecoronavirus,MERS-CoV)属于人类高致病性冠状病毒….其传染性强,病死率高,感染后的临床表现通常为发热、咳嗽、呼吸衰竭等呼吸系统症状[2].但对于SARS-CoV和MERS-CoV的感染尚且缺乏特效治疗药物,主要采取对症支持治疗,因而严重威胁了人类的生命安全[3].
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