低氧性肺动脉高压发生机制与诊治新策略
Chinese Journal of Lung Diseases (Electronic Edition)（2020）
Abstract
低氧性肺动脉高压(hypoxia pulmonary hypertension,HPH)是由于各种原因造成长期慢性缺氧,继而产生低氧性肺血管收缩(hypoxic pulmonary vasoconstriction,HPV)和低氧性肺血管结构重塑(hypoxic pulmonary vascular structural remodeling,HPVSR)[1],导致肺动脉压力异常增高的临床综合征,具有难治、高致残率与高病死率等特点[2].低氧性肺动脉高压的原发病因有慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)、间质性肺病(interstitial lung disease,ILD)、阻塞性睡眠呼吸暂停、长期高原生活缺氧等,世界卫生组织将其分为第Ⅲ组肺高血压(由肺部疾病和/或低血氧引发的肺高血压)[3],其发生机制尚未完全明了.
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