脑微出血对脑卒中溶栓预后影响的系统评价
Journal of Clinical Internal Medicine(2016)
Abstract
目的:评价脑微出血对卒中患者溶栓治疗的预后影响。方法计算机检索MEDLINE、The Cochrane Library、Pubmed、万方、维普中文科技期刊、中国生物医学文献及中国期刊网全文数据库,查找符合纳入标准的临床研究。应用 RevMan 5.3软件进行统计分析。结果纳入11篇文献,共2367例受试者。Meta 分析结果显示,脑微出血不一定增加溶栓后无症状性颅内出血[OR =0.46,95%CI(0.28,0.74),P =0.001]和总颅内出血[OR =1.03,95%CI(0.62,1.72), P =0.90],但可增加溶栓后症状性颅内出血[OR =1.95,95%CI(1.17,3.25),P =0.01],导致新发脑微出血[OR =10.71,95%CI(2.25,51.00),P =0.003];脑微出血对生存率无明显影响[OR =0.64,95%CI(0.38,1.09),P =0.10]。结论脑微出血可能是卒中患者溶栓治疗的危险因素。
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Key words
Microbleeds,Thrombolysis,Stroke,Systematic review,Observational study
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