从中医脾胃入手调控自噬对糖尿病肾病的影响
Chinese Journal of Integrated Traditional and Western Nephrology(2019)
Abstract
糖尿病肾病(diabetic kidley disease,DKD)是糖尿病最严重的慢性微血管并发症,已成为导致终末期肾病的主要原因,其发病机制涉及多种方面.研究表明[1,2],自噬是细胞生长发育、成熟分化及死亡的重要调控机制,对肾脏的结构与功能稳定起着重要作用,调节自噬障碍是DKD治疗的关键靶点.祖国医学认为脾胃气虚的发生可导致机体运化失常、卫外障碍,从而出现消化吸收、免疫、新陈代谢等功能紊乱,从而参与自噬障碍.鉴于脾胃病变与自噬之间的联系,本文拟探讨从中医脾胃入手调控自噬对DKD的影响.
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