固本通络方对IgA肾病患者血B细胞活化因子的影响
Chinese Journal of Integrated Traditional and Western Nephrology(2017)
Abstract
目的:观察固本通络方对IgA肾病患者血B细胞活化因子(B-cell activating factor,BAFF)的影响.方法:将85例IgA肾病(CKD1~4期)患者随机分为两组,治疗组43例给予固本通络方治疗,对照组42例给予科素亚治疗,疗程4个月.结果:(1)对照组24 h尿蛋白定量降低(P<0.05),治疗组尿红细胞数和24 h尿蛋白定量显著降低(P<0.01),组间疗效比较差异有统计学意义(P<0.05).(2)治疗组总有效率为74.4%,对照组总有效率为42.9%,组间疗效比较差异有统计学意义(P<0.05).(3)治疗组血BAFF水平有显著降低(P<0.01),对照组血BAFF水平有降低趋势,但差异无统计学意义(P>0.05);治疗组血BAFF水平的改善显著优于对照组(P<0.01).(4)治疗组血BAFF水平变化与尿红细胞数(r=0.8342,P<0.01)、24 h尿蛋白定量(r=0.5682,P<0.05)呈正相关.结论:固本通络方有效减少IgA肾病患者的血尿和蛋白尿,其机制可能与降低血BAFF水平相关.
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Key words
IgA nephropathy,B-cell activating factor,Guben Tongluo formula,Tiao He Ying Wei
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