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PD-1/PD-L1在支气管哮喘中的研究进展

International Journal of Respiration(2020)

Cited 2|Views7
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Abstract
支气管哮喘(哮喘)是一种由CD4 +T细胞、嗜酸性细胞、肥大细胞和嗜碱性细胞参与的慢性气道炎症。其中,T细胞亚群在协调气道炎症中起关键作用。最近,PD-1及其配体PD-L1,被证明可以调节T细胞的活化和耐受性,而PD-1被认为是传统CD4 +T细胞的负性调节因子。本文将阐述综近年来有关PD-1/PD-L1在哮喘中的研究进展,为促进发展制订新哮喘治疗方法提供思路。
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Key words
Asthma,Programmed cell death-1,Programmed cell death-ligands-1
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