Effect Of Cyp2c19 Gene Polymorphisms On Stent Thrombosis After Carotid Artery Stent Placement

Objective To clarify the relationship of CYP2C19 gene polymorphisms with stent thrombosis and the clopidogrel resistance after carotid artery stent(CAS) placement. Methods One hundred and two patients who firstly underwent carotid artery stent placement from January 2013 to December 2014 were enrolled in the department of neurology and geriatric neurology of Nanjing Brain Hospital. They were treated with aspirin 100 mg/d and clopidogrel 75 mg/d three days before CAS placement.CYP2C19 genotype was detected by improved multiple ligase detection reaction. The incidence rate of clopidogrel resistance and stent thrombosis was observed respectively. Results Of the 102 patients, 45 were wild?type homozygous, 47 were heterozygotes, and 10 were homozygous. The incidence rate of clopidogrel resistance was 26. 3%(15 cases) in patients with CYP2C19?2 gene, and 13. 3% (6 cases) in patients without CYP2C19?2 gene, and the difference between two groups was statistically significant (P<0. 05). The incidence rate of stent thrombosis was 19. 3%(11 cases) in patients with CYP2C19?2 gene, and 11. 1% (5 cases) in patients without CYP2C19?2 gene, and the difference between two groups was also statistically significant ( P<0. 05 ) . Conclusions CYP2C19 ? 2 loci polymorphism may be a risk factor for adverse events after CAS placement.