Nfr2与心血管系统疾病的相关性研究

Mao WANG, Guangying WANG,Di WANG,Ling WEI

Advances in Cardiovascular Diseases(2020)

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Abstract
核因子E2相关因子2(Nrf2)属于碱性亮氨酸转录家族成员,是抵抗细胞氧化应激的重要转录因子.Nrf2参与众多病理生理过程,Nrf2及下游靶基因的激活不仅能调控细胞氧化应激,还参与炎症反应和细胞自噬的调节.研究显示,Nrf2在心血管系统疾病的发生发展中发挥着重要作用.现就Nrf2与心血管系统疾病的相关性研究做一综述.
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