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血清颗粒蛋白前体与糖尿病及其微血管并发症的关系

Lijun Yao,Wenjun Wu,Yanmin Jiang,Lan Xu

International Journal of Endocrinology and Metabolism（2018）

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Abstract
血清颗粒蛋白前体(PGRN)是一种脂肪因子,与急慢性炎性反应、肿瘤、组织损伤修复有关.近年来发现,PGRN还参与糖尿病的发生,在糖尿病患者体内表达增加.PGRN可以通过白细胞介素-6炎性通路抑制胰岛素信号通路,促进胰岛素抵抗的发生.最近的研究表明,血清PGRN会随着糖尿病视网膜病变的进展而升高,而血清和尿PGRN与糖尿病肾病进展也密切相关,提示PGRN有望成为监测糖尿病微血管病变病情变化的一项指标.
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Key words
Progranulin,Insulin resistance,Diabetic microvasular complications
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