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表观遗传学与糖尿病及其并发症

Mei YANG,Jia-zhong SUN

International Journal of Endocrinology and Metabolism（2012）

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Abstract
表观遗传学是指在不改变基因组核苷酸序列的前提下,基因的表达水平与功能发生改变,并产生可遗传的表型.年龄、肥胖、营养和体育锻炼等环境因素与遗传因素相互作用,导致DNA甲基化,组蛋白修饰,RNA干扰等表观遗传修饰,促使免疫紊乱、炎性反应和胰岛素抵抗的发生,产生“代谢记忆”,参与糖尿病并发症的发生、发展.表观遗传机制在调控糖尿病病程中起了重要作用,其可逆转的特性为临床治疗和预防糖尿病并发症提供了新的思路.
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Key words
Epigenesis,Diabetes mellitus,Complications
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