继发性免疫性血小板减少症病因异质性及研究进展

Immune thrombocytopenic purpura (ITP) is an acquired disease with detectable autoantibodies against antigens on platelets' surface,which accelerate platelets' destruction and inhibit their production.In most cases,ITP are considered be idiopathic;whereas others are secondary to some well-defined causes including autoimmune disease,immunodeficiency and drug.Recent studies suggest that the proclivity to develop platelet-reactive antibodies in secondary ITP is resulted from diverse mechanisms.ITP secondary to an underlying condition is an exclusive diagnosis that is essential for improving treatment efficacy.Our review focuses on new advances of pathogenic and clinical diversity in several common secondary ITP.