基质金属蛋白酶与溶栓后出血性转化
FOREIGN MEDICAL SCIENCES(SECTION OF INTERNAL MEDICINE)（2006）
Abstract
溶栓能有效治疗急性缺血性卒中,但可发生严重的致命性颅内出血并发症.基质金属蛋白酶与脑缺血再灌注后脑血管壁破坏和血脑屏障通透性增加密切相关,而在脑缺血后早期应用基质金属蛋白酶抑制剂能显著降低溶栓后的出血发生率和严重程度.
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