miR-21-5p表达水平对溃疡性结肠炎的诊断价值
CHINESE JOURNAL OF INFLAMMATORY BOWEL DISEASES（2018）
Abstract
溃疡性结肠炎(ulcerative colitis,UC)是一种多始于直肠黏膜并逐渐向近端逆行性连续性发展的慢性非特异性炎性疾病,持续性或反复黏液血便和腹痛是UC的临床特征.近年的国内外流行病学统计数据显示,UC的发病率和患病率均呈现明显的增高趋势[1-2].微小RNA(miCroRNA,miRNA)与UC的发病及预后相关.miR-21在UC患者血清及肠黏膜组织中表达升高[37].在正常组织、UC相关不典型增生以及UC相关结肠癌的肠黏膜中,miR-21的表达量逐级递增[8].但血浆miR-21是否可用于UC诊断尚不清楚.本研究检测UC患者血浆miR-21-5p表达水平,探索其在UC中的诊断价值.
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