癌胚抗原嵌合锚定T细胞对胃癌的体内外抑癌效应观察
CHINESE JOURNAL OF SURGERY（2008）
Abstract
增强免疫水平对提高胃癌疗效十分重要,我们利用共刺激信号CD3ζ对T细胞的活化作用和抗癌胚抗原(CEA)单链抗体的识别功能,构建真核表达载体[1].在此基础上制备CEA阳性嵌合锚定T细胞,观察其对CEA阳性胃癌裸鼠的抑癌效应,以期探讨嵌合锚定T细胞对消化道肿瘤的治疗作用.
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